{"id":31293,"date":"2025-10-14T03:44:37","date_gmt":"2025-10-13T20:44:37","guid":{"rendered":"https:\/\/www.nanotec.or.th\/en\/?page_id=31293"},"modified":"2025-10-14T04:32:36","modified_gmt":"2025-10-13T21:32:36","slug":"ndx","status":"publish","type":"page","link":"https:\/\/www.nanotec.or.th\/en\/research-group\/rmns\/ndx\/","title":{"rendered":"NDx"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"31293\" class=\"elementor elementor-31293\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7a3992 e-con-full e-flex e-con e-parent\" data-id=\"c7a3992\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac53c0a elementor-widget elementor-widget-image\" data-id=\"ac53c0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2000\" height=\"774\" src=\"https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN.jpg\" class=\"attachment-full size-full wp-image-31501\" alt=\"\" srcset=\"https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN.jpg 2000w, https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN-300x116.jpg 300w, https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN-1024x396.jpg 1024w, https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN-768x297.jpg 768w, https:\/\/www.nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/3.-NDx-EN-1536x594.jpg 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c156c69 e-flex e-con-boxed e-con e-parent\" data-id=\"c156c69\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a4e3dc8 e-flex e-con-boxed e-con e-child\" data-id=\"a4e3dc8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33c460a elementor-align-center elementor-widget elementor-widget-button\" data-id=\"33c460a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-flask\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M437.2 403.5L320 215V64h8c13.3 0 24-10.7 24-24V24c0-13.3-10.7-24-24-24H120c-13.3 0-24 10.7-24 24v16c0 13.3 10.7 24 24 24h8v151L10.8 403.5C-18.5 450.6 15.3 512 70.9 512h306.2c55.7 0 89.4-61.5 60.1-108.5zM137.9 320l48.2-77.6c3.7-5.2 5.8-11.6 5.8-18.4V64h64v160c0 6.9 2.2 13.2 5.8 18.4l48.2 77.6h-172z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">NDx<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b80ab7 elementor-widget elementor-widget-heading\" data-id=\"2b80ab7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Nanodiagnostics Device Research Team<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6b148be e-flex e-con-boxed e-con e-child\" data-id=\"6b148be\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac5294e elementor-widget elementor-widget-text-editor\" data-id=\"ac5294e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Nanodiagnostics Device Research Team focuses on designing and developing screening technology systems for biomarker identification and detection at nanomolecular level. We aim to design and integrate targeting molecules with nanomaterials to develop simple, sensitive, and efficient biosensors \/ diagnostic \/ screening platform \/ devices in different fields of application. These applications include health &amp; biomedical, veterinary, and drug &amp; chemical contaminations in food &amp; drink applications.<\/p><p><img decoding=\"async\" class=\"size-large wp-image-29021 aligncenter\" src=\"http:\/\/www.nanotec.or.th\/th\/wp-content\/uploads\/2025\/10\/Ndx1-1024x564.jpg\" alt=\"\" width=\"1024\" height=\"564\" \/><\/p><ul><li><p><strong>Research Scope<\/strong><\/p><ol><li><strong> Biomarkers identification and analysis<\/strong><\/li><\/ol><ul><li>Target molecule selection<\/li><li>Nanopore technology, Surface Plasmon Resonance (SPR) technology, other related techniques for target biomolecule analysis<\/li><\/ul><ol start=\"2\"><li><strong> Design &amp; fabrication of nanomaterials and biomolecules for further use in detection &amp; screening<\/strong>.<\/li><\/ol><ul><li>Nanomaterials synthesis \u2013 Gold nanoparticle, Graphene oxide nanoparticle, Hybrid nanoparticle<\/li><li>Biomolecule design and fabrication \u2013 aptamers, specific peptide sequences<\/li><\/ul><ol start=\"3\"><li><strong> Integration of nanomaterial and biomolecules for designing and developing screening ang detection platform technology\u00a0<\/strong><\/li><\/ol><ul><li>Design and development of simple &amp; rapid biosensors using qualitative detection platform technology \u2013 Lateral Flow Immunochromatographic Assay, LFIA (sandwich and competitive technique), Colorimetric &amp; Fluorescence-based biosensors.<\/li><li>Design and development of sensitive and efficient biosensors using semi-quantitative detection platform technology \u2013 Electrochemical sensor, Surface Enhances Raman Scattering, SERS-based sensor, Dual E-chem &amp; Fluorescence-based sensor<\/li><\/ul><p><strong>\u00a0<\/strong><\/p><p><strong>Key Achievements<\/strong><\/p><ol><li><strong>Biomarkers identification for target molecule selection and designation<\/strong><\/li><\/ol><ul><li>Sudsat, P.; Srisala, J.; Pakotiprapha, D.; <strong>Tapaneeyakorn, S.<\/strong>; Sritunyalucksana, K.; Thitamadee, S.; Charoensutthivarakul, S.; Itsathitphaisarn, O. VP28 Interacts with PmRab7 Irrespective of Its Nucleotide State. <em> Rep.<\/em> <strong>2024,<\/strong> <em>Nov 13<\/em>,14(1):27803. <a href=\"https:\/\/doi.org\/10.1038\/s41598-024-79310-5\">https:\/\/doi.org\/10.1038\/s41598-024-79310-5<\/a><\/li><li>Archapraditkul, C.; Janon, K.; <strong>Japrung, D.<\/strong>; Pongprayoon, P. Structural and dynamic properties of urinary human serum albumin fragments: a molecular dynamics study. <em> Biomol. Struct. Dyn.<\/em> <strong>2024<\/strong>, <em>Sep;42(14)<\/em>, 7532-7540. <a href=\"https:\/\/doi.org\/10.1080\/07391102.2023.2240426\">https:\/\/doi.org\/10.1080\/07391102.2023.2240426<\/a><\/li><li>Alam, I.; Boonkoom, T.; Pitakjakpipop, H.; Boonbanjong, P.; Loha, K.; Saeyang, T.; Vanichtanankul, J.; <strong>Japrung, D.<\/strong> Single-Molecule Analysis of SARS-CoV-2 Double-Stranded Polynucleotides Using Solid-State Nanopore with AI-Assisted Detection and Classification: Implications for Understanding Disease Severity. <em>ACS Appl. Bio. Mater.<\/em> <strong>2024<\/strong> <em>Feb 19<\/em>, 7(2):1017-1027. <a href=\"https:\/\/doi.org\/10.1021\/acsabm.3c00998\">https:\/\/doi.org\/10.1021\/acsabm.3c00998<\/a><\/li><\/ul><ol start=\"2\"><li><strong>Design &amp; fabrication of nanomaterials and biomolecules for further use in detection &amp; screening<\/strong><\/li><\/ol><ul><li><strong>Ngamaroonchote, A.<\/strong>; <strong>Karn-Orachai, K.<\/strong> Bimetallic Au-Ag on a Patterned Substrate Derived from Discarded Blu-ray Discs: Simple, Inexpensive, Stable, and Reproducible Surface-Enhanced Raman Scattering Substrates. <strong>2021<\/strong> <em>Jun 22<\/em>, 37(24):7392-7404. <a href=\"https:\/\/doi.org\/10.1021\/acs.langmuir.1c00772\">https:\/\/doi.org\/10.1021\/acs.langmuir.1c00772<\/a><\/li><li>Apiwat, C.; Luksirikul, P.; Kankla, P.; Pongprayoon, P.; <strong>Treerattrakoon, K.<\/strong>; Paiboonsukwong, K.; Fucharoen, S.; Dharakul, T., <strong>Japrung, D.<\/strong> Graphene based aptasensor for glycated albumin in diabetes mellitus diagnosis and monitoring. <em> Bioelectron.<\/em> <strong>2016<\/strong> <em>Aug 15<\/em>, 82:140-5. <a href=\"https:\/\/doi.org\/10.1016\/j.bios.2016.04.015\">https:\/\/doi.org\/10.1016\/j.bios.2016.04.015<\/a><\/li><li><strong>Tapaneeyakorn, S.<\/strong>; Chantima, W.; Thepthai, C.; Dharakul, T. Production, characterization, and in vitro effects of a novel monoclonal antibody against Mig-7. <em> Biophys. Res. Commun.<\/em> <strong>2016<\/strong> <em>Jun 24<\/em>, 475(2):149-53. <a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.062\">https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.062<\/a><\/li><\/ul><ol start=\"3\"><li><strong>Integration of nanomaterial and biomolecules for designing and developing screening and detection platform technology<\/strong><\/li><\/ol><ul><li>Apiwat, C.; Houghton, J.W.; Ren, R.; Tate, E.; Edel, J.B.; Chanlek, N.; Luksirikul, P.; <strong>Japrung, D.<\/strong> Advancing Albumin Isolation from Human Serum with Graphene Oxide and Derivatives: A Novel Approach for Clinical Applications. <em>ACS Omega.<\/em> <strong>2024<\/strong> <em>Sep 20<\/em>, 9(39):40592-40607. <a href=\"https:\/\/doi.org\/10.1021\/acsomega.4c04276\">https:\/\/doi.org\/10.1021\/acsomega.4c04276<\/a><\/li><li><strong>Wiriyachaiporn, N<\/strong>.; Kongrueng, J.; Sukkuea, K.; Tanrattanawong, R.; Vanichtanankul, J.; Saeyang, T.; Jantra, T.; Japrung, D.; Maneeprakorn, W.; Bamrungsap, S.; Janchompoo, P.; Pasomsub, E. Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment. <em> Methods. <\/em><strong>2024<\/strong>, <em>May 3<\/em>, 16(17):2740-2750. <a href=\"https:\/\/doi.org\/10.1039\/d3ay02075d\">https:\/\/doi.org\/10.1039\/d3ay02075d<\/a><\/li><li>Pitikultham, P.; <strong>Putnin, T.<\/strong>; Pimalai, D.; Sathirapongsasuti, N.; Kitiyakara, C.; Jiang, Q.; Ding, B.; <strong>Japrung, D.<\/strong> Ultrasensitive Detection of MicroRNA in Human Saliva via Rolling Circle Amplification Using a DNA-Decorated Graphene Oxide Sensor. <em>ACS Omega.<\/em> <strong>2023<\/strong> <em>Apr 17<\/em>, 8(17):15266-15275. <a href=\"https:\/\/doi.org\/10.1021\/acsomega.3c00411\">https:\/\/doi.org\/10.1021\/acsomega.3c00411<\/a><\/li><li><strong>Karn-Orachai, K<\/strong>..; <strong>Ngamaroonchote, A<\/strong>. A label-free and selective SERS-based sensor for determination of ampicillin contamination in water using a fabric gold\u2013silver alloy substrate with a handheld Raman spectrometer <em>New J. Chem.<\/em> <strong>2023<\/strong> <em>47<\/em>, 2758-2770. <a href=\"https:\/\/doi.org\/10.1039\/D2NJ05346B\">https:\/\/doi.org\/10.1039\/D2NJ05346B<\/a><\/li><li>Sangkaew, P.; <strong>Ngamaroonchote, A.<\/strong>; Sanguansap, Y.; <strong>Karn-orachai, K.<\/strong> Emerging Electrochemical Sensor Based on Bimetallic AuPt NPs for On-Site Detection of Hydrogen Peroxide Adulteration in Raw Cow Milk. <em>Electrocatalysis<\/em> <strong>2022<\/strong> <em>13<\/em>, 794\u2013806. <a href=\"https:\/\/doi.org\/10.1007\/s12678-022-00763-1\">https:\/\/doi.org\/10.1007\/s12678-022-00763-1<\/a><\/li><li><strong>Putnin, T.<\/strong>; Waiwinya, W.; Pimalai, D.; <strong>Chawjiraphan, W.<\/strong>; Sathirapongsasuti, N.; <strong>Japrung, D.<\/strong> Dual sensitive and rapid detection of glycated human serum albumin using a versatile lead\/graphene nanocomposite probe as a fluorescence-electrochemical aptasensor. <strong>2021<\/strong> <em>Jul 7<\/em>, 146(13):4357-4364. <a href=\"https:\/\/doi.org\/10.1039\/d1an00556a\">https:\/\/doi.org\/10.1039\/d1an00556a<\/a><\/li><li><strong>Wiriyachaiporn, N.<\/strong>; Sirikaew, S.; Bamrungsap, S.; Limcharoen, T.; Polkankosit, P.; Roeksrungruang, P.; Ponlamuangdee, K. A simple fluorescence-based lateral flow test platform for rapid influenza B virus screening. <em> Methods.<\/em> <strong>2021<\/strong> Apr 14, 13(14):1687-1694. <a href=\"https:\/\/doi.org\/10.1039\/d0ay01988g\">https:\/\/doi.org\/10.1039\/d0ay01988g<\/a><\/li><li><strong>Chawjiraphan, W.<\/strong>; Apiwat, C.; Segkhoonthod, K.; <strong>Treerattrakoon, K<\/strong>.; Pinpradup, P.; Sathirapongsasuti, N.; Pongprayoon, P.; Luksirikul, P.; Isarankura-Na-Ayudhya, P.; <strong>Japrung, D.<\/strong> Albuminuria detection using graphene oxide-mediated fluorescence quenching aptasensor. <em>MethodsX<\/em>. <strong>2020<\/strong> <em>Oct 20<\/em>, <a href=\"https:\/\/doi.org\/10.1016\/j.mex.2020.101114\">https:\/\/doi.org\/10.1016\/j.mex.2020.101114<\/a><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b616ca5 e-flex e-con-boxed e-con e-parent\" data-id=\"b616ca5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9cc680f e-flex e-con-boxed e-con e-child\" data-id=\"9cc680f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-096d0e4 e-con-full e-flex e-con e-child\" data-id=\"096d0e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-84872c2 elementor-widget elementor-widget-text-editor\" data-id=\"84872c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Current research projects<\/strong><\/p><ol><li>Development and application of portable nanosensor for screening and monitoring of Diabetes mellitus and chronic kidney disease<\/li><li>Development of nanosensor and nanopore technology platform for non-communicable disease screening and monitoring<\/li><li>Development of an Albumin and Glycated Albumin Test Kit for Screening Kidney Disease and Diabetes Mellitus<\/li><li>Advancing Innovation in Screening and Monitoring Chronic Kidney Disease and Diabetic Complications for Integration into the Thai Healthcare System and Supporting Thailand\u2019s Development as a Medical Hub<\/li><li>Commercial application of AL-Strip<\/li><li>Study structure and function of human serum albumin (HSA) in urine sample for development of chronic kidney disease (CKD) screening<\/li><li>Development of rapid albumin test kit for screening of chronic kidney disease in the Northeastern Thailand<\/li><li>Rapid Lateral Flow Test for Point-of-Care Screening of COVID-19<\/li><li>Easy-to-Use Screening Platform with Smartphone Assisted Technology for a Pathogen Detection using Influenza-like Illness (ILI) Virus as a Model<\/li><li>Dextran test kit for dextran determination in the sugar industry<\/li><li>Development of Detection Method for Bacteria in Raw Milk Using Electrochemical technique<\/li><li>Development of nanoscale materials for non-enzymatic determination of chemical substance in urine using electrochemical and surface-enhanced Raman scattering techniques<\/li><li>Quantitative detection of hydrogen peroxide in raw milk using electrochemical technique<\/li><li>Fabrication of SERS substrate by developing nanostructured surface from BD-ROM<\/li><li>Development of polymer structure for using instead of biomolecules in the application of SERS biosensor<\/li><\/ol><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c73c949 e-con-full e-flex e-con e-child\" data-id=\"c73c949\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-ee9e455 e-con-full e-flex e-con e-child\" data-id=\"ee9e455\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-586c28e elementor-widget elementor-widget-heading\" data-id=\"586c28e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Contact Us<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ae1f7b elementor-widget elementor-widget-spacer\" data-id=\"6ae1f7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2fc55a elementor-align-center elementor-widget elementor-widget-button\" 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Nanodiagnostics Device Research Team focuses on designing and developing screening technology systems for biomarker identification 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