{"id":3576,"date":"2012-04-26T14:25:32","date_gmt":"2012-04-26T07:25:32","guid":{"rendered":"https:\/\/nano2.toolsmkt.com\/?p=3576"},"modified":"2012-04-26T14:25:32","modified_gmt":"2012-04-26T07:25:32","slug":"gold-nanoparticles-detect-salmonella-on-food","status":"publish","type":"post","link":"https:\/\/www.nanotec.or.th\/en\/gold-nanoparticles-detect-salmonella-on-food\/","title":{"rendered":"Gold nanoparticles detect salmonella on food"},"content":{"rendered":"<p>Gold nanoparticles can help identify Salmonella in five minutes, which is considerably faster than the 12-24 hours required to grow a reliable culture in a lab.<!--more--><\/p>\n<p>Paresh Ray, who led the research, explained that the test fulfills an urgent need for a faster way to detect Salmonella, especially the multiple-drug resistant (MDR) strains that cause the most serious disease in both food and drinking water. In the U.S., Salmonella-contaminated food causes at least 1.6 million cases of food poisoning annually. Elsewhere in the developing world, drinking water contaminated with MDR Salmonella causes terrible outbreaks of typhoid fever, which strikes at least 17 million people annually.\u00a0<\/p>\n<p>\u201cThe test for lettuce requires just a tiny sample of lettuce leaf,\u201d Ray explained. \u201cIt doesn\u2019t take a trained laboratory technician to perform the test or read the results. If the colourr changes from pink to bluish, that signals the presence of Salmonella. The test is suitable for use in farm fields and in remote areas of the developing world. We believe it may have enormous potential for rapid, on-site pathogen detection to avoid the distribution of contaminated foods.\u201d\u00a0<\/p>\n<p>To find the bacteria faster, Ray and colleagues at\u00a0<a href=\"http:\/\/www.jsums.edu\/\" target=\"_blank\">Jackson State Univ. in Mississippi<\/a> enlisted gold nanoparticles, vanishingly small bits of gold so tiny that more than 25,000 would fit across the width of a human hair. The researchers attached antibodies, molecules similar to the ones that help the immune system find and fight infections with Salmonella, to the nanoparticles. Viewed under a powerful microscope, the gold nanoparticles look somewhat like individual pieces of popcorn. When these antibodies encounter Salmonella bacteria, they attach to the outer surface of the bacteria, carrying along their cargo of gold popcorn-shaped nanoparticles. The nanoparticle-antibody package is much smaller than an individual Salmonella bacterium, and several attach to each bacterium. The test, with its pink-to-blue color change, detects those gold nanoparticle-antibody-Salmonella structures, which Ray calls \u201caggregates.\u201d\u00a0<\/p>\n<p>The approach also has potential for killing MDR Salmonella, Ray says. \u201cWhen you shine the right wavelength of light into contaminated water, for instance, the gold nanoparticles absorb that light and heat up,\u201d he explained. \u201cThose hot particles burn through the outer membrane of the Salmonella bacteria, killing the bacteria.\u201d\u00a0 Ray and colleagues first developed the popcorn-shaped particles to find and fight cancer. The shape was chosen because it boosts the signal for detection using something called Raman spectroscopy, which looks at the light given off after atoms or molecules absorb energy. Ray explained that this detection method is useful in other applications of the particles. \u201cIn science, we call that the lightning rod effect,\u201d says Ray, describing how the splayed \u201ctips\u201d of the popcorn shape enhance the signal and make it easier to see. The group has also used the nanoparticles to detect other microbes, like E. coli.\u00a0<\/p>\n<p>Despite gold\u2019s stature as a precious and very costly metal, only tiny amounts are needed, Ray noted. About $90 worth of gold is enough to make gallons of the solution containing the nanoparticles. And only a few drops of the solution are needed seek out Salmonella bacteria.\u00a0<\/p>\n<p>Ray says the technology can be commercialized, and a patent is pending. With concerns about the potential health and environmental effects of many kinds of nanoparticles, Ray\u2019s team is investigating the effects of gold nanoparticles remaining in purified water, for instance. So far, they have found no short-term toxicity and will be checking on any potential long-term toxicity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gold nanoparticles can help identify Salmonella in five minutes, which is considerably faster than the 12-24 hours required to grow [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[34],"tags":[],"class_list":["post-3576","post","type-post","status-publish","format-standard","hentry","category-technology-update"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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