The National Nanotechnology Initiative (NNI) Workshop on Regional, State, and Local (RSL) Initiatives in Nanotechnology was held 1–2 May 2012 in Portland, Oregon. This was the fourth in a series of RSL workshops sponsored by the NNI since 2003.1 RSL organizations have vital roles in establishing the infrastructure, preparing the skilled workforce, and supporting the industries—especially startups and small and medium enterprises (SMEs)—that are critical to building an economically viable nanotechnology innovation ecosystem in the United States.

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